Host Endoplasmic Reticulum Stress and Interferon Responses Contribute to AAV-Induced Ocular Toxicity
Apolonia Gardner, Christin M. Hong, Sophia R. Zhao, Adam J. Daniels, Constance L. Cepko
In neonatal mice, AAV-driven GFP overexpression in RPE shows ER stress signatures and partly CHOP-dependent RPE damage, while IFNAR loss partly spares photoreceptors.
bioRxiv · Sep 23, 2026 · PreprintGenetics✦ In-depth digest