Sophia R. Zhao

In neonatal mice, AAV-driven GFP overexpression in RPE shows ER stress signatures and partly CHOP-dependent RPE damage, while IFNAR loss partly spares photoreceptors.

This paper develops humanized extracellular vesicles for efficient RNA delivery, achieving titers comparable to lentiviral vectors with reduced immunogenicity.

This paper tests AAV8/Best1-Nrf2 gene therapy in rodent models of oxidative stress, showing protection of retinal cells and preservation of visual function.