Apolonia Gardner

In neonatal mice, AAV-driven GFP overexpression in RPE shows ER stress signatures and partly CHOP-dependent RPE damage, while IFNAR loss partly spares photoreceptors.

This study shows that AAV-NRF2 protects retinal and choroidal vasculature in an oxidative damage model of AMD through GDF15, reducing inflammation and oxidative stress.

This paper tests AAV8/Best1-Nrf2 gene therapy in rodent models of oxidative stress, showing protection of retinal cells and preservation of visual function.

The paper describes the development of a congenic C57BL/6 rd1 mouse model to improve retinal degeneration research by reducing genetic variability.

This study shows that increasing MCT2 in RPE cells improves cone survival in RP models by enhancing lactate uptake and glucose transport.