Evolution toward larger cell size reduces internal cellular density
Alexander Sastokas, Wei-Chin Ho, Kara Schmidlin, Mansi Bhatt, Peter Brown, Parker Crossland, Adam Kindelin, Zerrin Üzüm, Douglas P. Shepherd, Michael Lynch, Kerry Geiler‐Samerotte
This study shows that evolving larger cell size reduces internal cellular density, as material accumulation does not keep pace with volume increase, both in experimental evolution and across species.
bioRxiv · Nov 5, 2025 · PreprintBiophysics