Kerry Geiler‐Samerotte

Dissecting genetic correlation and pleiotropy through a genetic cross

This paper introduces a method using genetic crosses to assess developmental bias and genetic correlation stability across conditions.

Evolutionary adaptation proceeds through a small number of phenotypic modules

The paper shows that fitness variation across drug environments in yeast is organized by a low-dimensional phenotypic structure, revealing modular phenotypic modules that constrain adaptive mutations.

Evolution toward larger cell size reduces internal cellular density

This study shows that evolving larger cell size reduces internal cellular density, as material accumulation does not keep pace with volume increase, both in experimental evolution and across species.

Environment by environment interactions (ExE) differ across genetic backgrounds (ExExG)

The paper investigates environment-by-environment interactions (ExE) across genetic backgrounds (ExExG) in yeast, showing that drug combinations vary in effectiveness among mutants and introducing a new predictive framework.

Collateral fitness effects of mutation are not commonly caused by protein misfolding

The paper tests if protein misfolding causes collateral fitness effects from mutations and finds it is not common, but misfolding does drive primary fitness costs when function is essential.

Unstressed cells are alike, but stressed cells differ: Environmental and single-cell heterogeneity in yeast stress responses

The paper uses single-cell RNA sequencing to analyze stress responses in yeast, finding that stressed cells show more variability than unstressed cells and that population-level analyses can obscure individual differences.

INgen: Intracellular Genomic DNA Amplification for Downstream Applications in Sequencing and Sorting

INgen enables DNA amplification within fixed cells, overcoming limitations in single-cell genomics by allowing sequencing without physical cell isolation.

An ultra high-throughput, massively multiplexable, single-cell RNA-seq platform in yeasts

This paper introduces a high-throughput single-cell RNA-seq platform for yeasts that enables multiplexing of hundreds of strains and environments, revealing transcriptional heterogeneity within clonal populations.

The complete genome sequence of the Staphylococcus bacteriophage Metroid

The paper characterizes the complete genome of the Staphylococcus bacteriophage Metroid and compares it to other cluster C1 phages, highlighting similarities in the lysis cassette.