The 1000+ mouse project: large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies
Adam L Kenet, Sooraj R. Achar, Alka Dwivedi, John Buckley, Marie Pouzolles, Haiying Qin, Christopher Daniel Chien, Naomi N. Taylor, Grégoire Y Altan-Bonnet
The paper introduces maRQup, a method for analyzing bioluminescent tumor images in over 1,000 mice, showing CD28 CAR-T cells initially control tumors better than 4-1BB CAR-T cells, which reduce relapse frequency.
bioRxiv · Mar 17, 2025Immunology