Grégoire Y Altan-Bonnet

This study identifies design principles of cytotoxic CD8+ T-cell responses by modeling them as feedback-controlled programs, revealing trade-offs between infection clearance and immunopathology, and suggesting strategies for improving T-cell therapies.

This paper introduces a capture assay to measure single-cell antibody secretion in B cells during plasma cell differentiation.

This paper develops a dynamical model of the immune system that supports the discontinuity theory by showing how immune responses depend on the rate of antigenic change, with implications for infections and vaccination.

The paper introduces maRQup, a method for analyzing bioluminescent tumor images in over 1,000 mice, showing CD28 CAR-T cells initially control tumors better than 4-1BB CAR-T cells, which reduce relapse frequency.

The paper studies chaotic dynamics in hematopoiesis using mouse data, showing leukocyte fluctuations are chaotic and can transition to oscillations with B cell accumulation.

The paper investigates how receptor and kinase abundance imbalances affect cytokine signaling in T cells, finding that higher receptor levels can weaken signaling responses.

This paper introduces a novel hierarchical density clustering algorithm, HAL-x, which efficiently generates multiple cluster labels for single-cell data and achieves high accuracy in classifying clinical statuses.