Author

Christopher Daniel Chien

National Cancer InstituteORCID 0000-0002-4871-5262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Naomi N. TayloriD· 2 shared Adam L Kenet· 1 shared Aidan Pursley· 1 shared Alka DwivediiD· 1 shared Amanda Lin CheniD· 1 shared Catherine M. AdeiD· 1 shared Grégoire Y Altan-BonnetiD· 1 shared Haiying QiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Naomi N. TaylorORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

HLA-A*11:01-Restricted T Cell Receptors Targeting Mutant NPM1 for Adoptive Cell Therapy in Acute Myeloid Leukemia

Aidan Pursley, Uns Kirmani, Amanda Lin Chen, Zhiya Yu, Ken‐ichi Hanada, Catherine M. Ade, Christopher Daniel Chien, Nuri Cha, Willy A. Flegel, Peter D. Aplan, Martin P Carroll, Naomi N. Taylor, James Chih-Hsin Yang, Steven Zivko Pavletic, Sung‐Yun Pai, Vid Leko

This study identifies two TCRs targeting mutant NPM1 in AML for adoptive therapy, showing specific anti-leukemic activity without cross-reactivity.

bioRxiv · Oct 1, 2026 · PreprintImmunology

The 1000+ mouse project: large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

Adam L Kenet, Sooraj R. Achar, Alka Dwivedi, John Buckley, Marie Pouzolles, Haiying Qin, Christopher Daniel Chien, Naomi N. Taylor, Grégoire Y Altan-Bonnet

The paper introduces maRQup, a method for analyzing bioluminescent tumor images in over 1,000 mice, showing CD28 CAR-T cells initially control tumors better than 4-1BB CAR-T cells, which reduce relapse frequency.

bioRxiv · Mar 17, 2025Immunology