Ketamine Modulates Endogenous Opioid Peptide Signaling and Reduces Heroin-Seeking in Male Long-Evans Rats
Adam M Dawoud, Achla Gupta, Ivone Gomes, Dylan Baker, Julia E Shapiro, Lakshmi Devi, Yasmin L. Hurd, Aya Osman
This study shows ketamine reduces heroin-seeking in rats by modulating endogenous opioid and glutamatergic systems, suggesting its potential as an OUD treatment.
bioRxiv · Sep 6, 2026 · PreprintNeuroscience