Author

Adam Walter

Children's Mercy Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:variant calling· 3 Assay:long-read sequencing· 2 Assay:whole-genome sequencing· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Asher BryantiD· 3 shared Ayşe Gökçe KeşküşiD· 3 shared Byunggil YooiD· 3 shared Chengpeng Bi· 3 shared Irina PusheliD· 3 shared Lisa A. LansdoniD· 3 shared Margaret Gibson· 3 shared Midhat S. FarooqiiD· 3 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Asher BryantORCID

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3 papers

Recent·Most cited

DeepSomatic: Accurate somatic small variant discovery for multiple sequencing technologies

Jimin Park, Daniel E. Cook, Pi-Chuan Chang, Alexey Kolesnikov, Lucas Brambrink, Juan Carlos Mier, Joshua M.V. Gardner, Brandy McNulty, Samuel Sacco, Ayşe Gökçe Keşküş, Asher Bryant, Tanveer Ahmad, Jyoti Shetty, Yongmei Zhao, Bao Quoc Tran, , Kishwar Shafin

DeepSomatic is a deep learning method for detecting somatic variants from short-read and long-read sequencing data, outperforming existing callers, especially for indels.

Nature Biotechnology · Oct 16, 2025Peer-reviewedBioinformatics

Severus: accurate detection and characterization of somatic structural variation in tumor genomes using long reads

Ayşe Gökçe Keşküş, Asher Bryant, Tanveer Ahmad, Byunggil Yoo, Sergey S. Aganezov, Anton Goretsky, Ataberk Donmez, Lisa A. Lansdon, Isabel Rodriguez, Jimin Park, Yuelin Liu, Xiwen Cui, Joshua Gardner, Brandy McNulty, Samuel Sacco, , Mikhail Kolmogorov

Severus detects and characterizes somatic structural variations in tumor genomes using long reads, outperforming existing methods in accuracy and revealing clinically relevant rearrangements.

Nature Biotechnology · Apr 4, 2025Peer-reviewedGenetic & Genomic Medicine

Successful classification of clinical pediatric leukemia genetic subtypes via structural variant detection using HiFi long-read sequencing

Lisa A. Lansdon, Byunggil Yoo, Ayşe Gökçe Keşküş, Irina Pushel, Chengpeng Bi, Tanveer Ahmad, Asher Bryant, Adam Walter, Margaret Gibson, Mary Rindler, Weijie Li, Sultan S. Habeebu, Linda D. Cooley, John C. Herriges, Elena A. Repnikova, , Midhat S. Farooqi

This study shows that HiFi long-read sequencing can detect clinically relevant structural variants in pediatric leukemia, improving subtype classification.

medRxiv · Nov 5, 2024 · PreprintGenetic & Genomic Medicine