Samuel Sacco

This study uses DNA from museum hair samples to confirm Thomas Jefferson's ancestry in descendants of Sally Hemings and Martha Wayles Jefferson, supporting paternity over alternative explanations.

This study uses ancient and modern bison genomes to show past population connectivity and reveal human impacts on bison diversity, informing conservation efforts.

This study uses paleogenomes of dire wolves to resolve their evolutionary relationships and identify genes under diversifying selection.

The paper presents a chromosome-level genome assembly for the Western Spadefoot, Spea hammondii, using long-read and proximity ligation data, enabling population genomic studies for conservation.

Wakhan reconstructs chromosome-scale copy number profiles of tumor genomes using long-read sequencing, showing better consistency with data than existing methods.

DeepSomatic is a deep learning method for detecting somatic variants from short-read and long-read sequencing data, outperforming existing callers, especially for indels.

Hi-reComb estimates recombination maps from bulk gamete Hi-C data, showing accurate results in fish sperm and enabling structural variant analysis.

This study shows Wolbachia infection changes host cell states in Drosophila cell lines, affecting gene expression and chromatin structure, and suggests these changes determine symbiotic outcomes.

The paper presents haplotype-resolved genomes of six ape species with high accuracy and provides comparative analyses to study evolutionary diversity and gene family evolution.

Severus detects and characterizes somatic structural variations in tumor genomes using long reads, outperforming existing methods in accuracy and revealing clinically relevant rearrangements.

The paper produces gapless assemblies of ape sex chromosomes for five great apes and a lesser ape, revealing divergence in Y chromosomes and evolutionary dynamics.

The paper uses museum genomics to compare historical and contemporary steelhead populations, finding minimal introgression and a decline in migration-associated haplotypes over time.

The paper introduces Minigraph-Cactus, a pangenome pipeline that constructs pangenome graphs directly from whole-genome alignments, demonstrating improved performance in mapping and variant calling across human and Drosophila data.

The paper presents a draft human pangenome reference that improves variant discovery and structural variant detection compared to existing references.

The paper shows recombination between heterologous human acrocentric chromosomes using pangenome data, revealing pseudo-homologous regions linked to Robertsonian translocations.