Beta-arrestin-mediated Angiotensin II type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension
Zhiyuan Ma, Gayathri Viswanathan, Mason Sellig, Chanpreet Jassal, Issac Choi, Aditi Garikipati, Xinyu Xiong, Nour Nazo, Sudarshan Rajagopal
This study evaluates a beta-arrestin-biased AT1R agonist in PAH models, finding it fails to improve survival compared to AngII but promotes vascular remodeling.
JACC Basic to Translational Science · Nov 1, 2021Peer-reviewedMolecular Biology