Sudarshan Rajagopal

BCKDK Inhibitors Directly Antagonize Angiotensin II Type 1 Receptor and Induce Vasodilation Independently of BCAA Catabolism or BCKDK

This study shows BCKDK inhibitors cause vasodilation by directly blocking the AT1R, independent of BCAA catabolism or BCKDK.

β-arrestin recruitment facilitates a direct association with G proteins

This study shows that G proteins and β-arrestins can directly interact, with Gi family members differing in their association with β-arrestin, and this selectivity is located in the alpha helical domain of Gi.

Small-molecule modulation of Beta-arrestins

This study identifies small-molecule inhibitors of beta-arrestins and elucidates their mechanism, offering a framework for modulating GPCR signaling.

β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function

This study shows β-arrestin condensates regulate GPCR function through liquid-liquid phase separation, influencing internalization and signaling.

Location-biased β-arrestin conformations direct GPCR signaling

This study shows that β-arrestin conformations vary by subcellular location and influence ERK activation differently in response to agonists.

CXCR1 and CXCR2 display receptor bias for shared chemokine agonists

The paper shows that CXCL1 acts as a G protein-biased partial agonist at CXCR1 but a balanced full agonist at CXCR2, revealing receptor bias in chemokine signaling.

Endothelial beta-arrestins Regulate Mechanotransduction by the Type II Bone Morphogenetic Protein Receptor in Primary Cilia

This paper identifies beta-arrestins as key regulators of ciliary mechanotransduction in endothelial cells, showing their role in shear stress response and vascular development.

Beta-arrestin-mediated Angiotensin II type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension

This study evaluates a beta-arrestin-biased AT1R agonist in PAH models, finding it fails to improve survival compared to AngII but promotes vascular remodeling.