Author

Issac Choi

Duke Medical CenterORCID 0000-0001-7429-8418Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:rat· 1

Frequent Co-Authors

Chanpreet JassaliD· 2 shared Sudarshan RajagopaliD· 2 shared Abigail GilmeriD· 1 shared Aditi Garikipati· 1 shared Andrew C. KruseiD· 1 shared Andrew N. DatesiD· 1 shared Ari S. HilibrandiD· 1 shared Claudia Y. LeeiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

Chanpreet JassalORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJul 17, 2026

β-arrestin recruitment facilitates a direct association with G proteins

Claudia Y. Lee, Jeffrey S. Smith, Taylor Kohlmann…·Sudarshan Rajagopal

This study shows that G proteins and β-arrestins can directly interact, with Gi family members differing in their association with β-arrestin, and this selectivity is located in the alpha helical domain of Gi.

DOI 10.1038/s41467-026-74944-7

experimental assaycell signaling & trafficking

𝕏 PostBluesky

Molecular BiologyJACC Basic to Translational SciencePeer-reviewedNov 1, 2021

Beta-arrestin-mediated Angiotensin II type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension

Zhiyuan Ma, Gayathri Viswanathan, Mason Sellig…·Sudarshan Rajagopal

This study evaluates a beta-arrestin-biased AT1R agonist in PAH models, finding it fails to improve survival compared to AngII but promotes vascular remodeling.

24 citations

ratexperimental assay

𝕏 PostBluesky