AGS3-based optogenetic GDI induces GPCR-independent Gβγ signaling and macrophage migration
Waruna Thotamune, Sithurandi Ubeysinghe, Chathuri Rajarathna, Dinesh Kankanamge, Koshala Olupothage, Aditya Chandu, Bryan A. Copits, Ajith Karunarathne
This study introduces an optogenetic GDI tool to induce Gβγ signaling independently of GPCRs and demonstrates its ability to trigger macrophage migration.
bioRxiv · Jun 4, 2024 · PreprintMolecular Biology