Ajith Karunarathne

Novel GαGTP Sensors Reveal Endogenous and Subcellular G Protein Signaling Dynamics

This paper introduces novel GαGTP sensors to measure endogenous G protein signaling dynamics, revealing subtype-dependent dissociation and subcellular regulation.

AGS3-based optogenetic GDI induces GPCR-independent Gβγ signaling and macrophage migration

This study introduces an optogenetic GDI tool to induce Gβγ signaling independently of GPCRs and demonstrates its ability to trigger macrophage migration.

Spatiotemporal optical control of Gαq-PLCβ interactions

This paper introduces an optogenetic tool to control GqGTP-PLCβ interactions and shows its role in regulating cell migration through competition with RhoGEFs.