RNA language models predict mutations that improve RNA function
Yekaterina Shulgina, Marena I. Trinidad, Conner J. Langeberg, Hunter M. Nisonoff, Seyone Chithrananda, Petr Skopintsev, Amos J. Nissley, Jaymin R. Patel, Ron S. Boger, Honglue Shi, Peter H. Yoon, Erin E. Doherty, Tara Pande, Aditya M. Iyer, Jennifer A. Doudna, Jamie H. D. Cate
The paper develops an RNA language model to predict mutations that enhance RNA thermostability using a new database of RNA sequences linked to environmental temperatures.
Nature Communications · Dec 5, 2024Peer-reviewedSynthetic Biology