Conner J. Langeberg

Improving RNA Secondary Structure Prediction Through Expanded Training Data

The paper improves RNA secondary structure prediction by training a deep learning model on a new dataset of RNA sequences and structures, showing better generalization to unseen RNA families.

Stepwise DNA unwinding gates TnpB genome-editing activity

Ymu1 TnpB unwinds DNA via a long-lived partially unwound intermediate before a rarely stable open state; the WFR triple variant stabilizes both, boosting plant editing.

Structure and evolution-guided design of minimal RNA-guided nucleases

The paper designs active RNA-guided nucleases using AI and structure-guided methods, validated by cryo-EM and functional testing across species.

A Noncontiguous Code for RNA-Guided DNA Recognition Preceded CRISPR

The paper identifies VIPR systems, which use noncontiguous RNA codes for DNA recognition, suggesting an ancient origin of adaptive immunity through viral interactions.

Tick-borne flavivirus exoribonuclease-resistant RNAs contain a 'double loop' structure

The paper identifies and characterizes a novel 'double loop' structure in tick-borne flavivirus xrRNAs, revealing a conserved mechanism of exoribonuclease resistance.

A conserved class of viral RNA structures regulate translation reinitiation through dynamic ribosome interactions

The paper identifies and characterizes viral RNA structures that regulate translation reinitiation through ribosome interactions, revealing conserved features and dynamic conformations.

RNA language models predict mutations that improve RNA function

The paper develops an RNA language model to predict mutations that enhance RNA thermostability using a new database of RNA sequences linked to environmental temperatures.

RNA elements required for the high efficiency of West Nile Virus-induced ribosomal frameshifting

This study identifies RNA elements critical for high-efficiency ribosomal frameshifting in West Nile Virus, revealing structural and sequence requirements and implications for antiviral strategies.