Jaymin R. Patel

Half-match recombination drives bridge RNA-guided excision and off-target insertion

The paper demonstrates that half-match recombination, independent of target-site complementarity, drives bridge RNA-guided excision and off-target insertion in IS621 recombination.

Bridge recombinase enables versatile rewriting of bacterial genomes

This paper introduces bridge recombinase for versatile genome editing in bacteria, achieving large insertions, inversions, and excisions across multiple phyla and gut communities.

Generating functional plasmid origins with OriGen

OriGen generates and validates new plasmid origins of replication, demonstrating its ability to create functional sequences distinct from existing wild types.

RNA language models predict mutations that improve RNA function

The paper develops an RNA language model to predict mutations that enhance RNA thermostability using a new database of RNA sequences linked to environmental temperatures.