Yekaterina Shulgina

tRNA-derived second messengers confer bacterial immunity

The paper identifies a bacterial immune pathway where tRNA cleavage generates second messengers that trigger cell death via RNA-guided nuclease activity.

Enzymatic formation of a conserved isoaspartate in ribosomal protein uS11

The paper identifies an enzymatic pathway for isoaspartate formation in bacterial ribosomal protein uS11, showing its conservation and structural importance.

A family of archaeal hibernation factors that bind in tandem and protect ribosomes in dormant cells

This study identifies a family of archaeal hibernation factors that bind to ribosomes in tandem and protect them during dormancy.

A threonine-to-aspartate ACA codon reassignment in uncultivated Acidimicrobiales bacteria

The paper identifies a novel sense-to-sense codon reassignment in Acidimicrobiales bacteria where ACA specifies aspartate instead of threonine.

Structure of an Archaeal Ribosome with a Divergent Active Site

The paper identifies divergent ribosomal RNA sequences in the PTC of archaea and determines their structure, revealing sequence variation and a novel hibernation factor.

RNA language models predict mutations that improve RNA function

The paper develops an RNA language model to predict mutations that enhance RNA thermostability using a new database of RNA sequences linked to environmental temperatures.

A computational screen for alternative genetic codes in over 250,000 genomes

The paper develops a computational method to identify alternative genetic codes in bacterial and archaeal genomes, discovering new codon reassignments and their evolutionary drivers.

Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

The paper investigates the HbP2 enhancer in Drosophila, showing that cooperative binding of Bcd is insufficient to explain its sharp expression pattern, and identifies other factors like pioneer factors and histone modifiers as key contributors.