TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms
Megan M. Dykstra, Kaitlin Weskamp, Nicolás Gómez, Jacob Waksmacki, Elizabeth M.H. Tank, M. Rebecca Glineburg, Allison G. Snyder, Emile S. Pinarbasi, Michael E. Bekier, Xingli Li, Jen Bai, Shameena Shahzad, Juno Nedumaran, Clare M. Wieland, Corey Stewart, , Sami J. Barmada
This study identifies TDP43 autoregulation as a source of shortened isoforms, showing they are regulated by NMD and post-translational degradation, and their dysregulation leads to neurodegeneration.
bioRxiv · Jul 2, 2024 · PreprintNeuroscience