Author

Clare M. Wieland

University of MichiganORCID 0000-0002-7129-3475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:long-read sequencing· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Peter K. ToddiD· 4 shared Amy Krans· 3 shared Elizabeth M.H. TankiD· 2 shared Erinn L. Laimon-Thomson· 2 shared Ishita Purwar· 2 shared Sami J. BarmadaiD· 2 shared Sydney WilleyiD· 2 shared Aditya V. Suryakumar· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersNeuroscience

Peter K. ToddORCID

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4 papers

Recent·Most cited

Structural basis for repeat-associated non-AUG translation initiation on C9orf72 mRNA

Ross T. Kaufhold, Wenzhao Dong, Ishita Purwar, Brenna A Saladin, Clare M. Wieland, Amy Krans, Erinn L. Laimon-Thomson, Indranil Malik, Suada Leskaj, Tal Havilio, Masaaki Sokabe, Christopher S. Fraser, Peter K. Todd, Jailson Brito Querido

The paper determines the structure of C9orf72 RAN translation initiation complexes and identifies a key RNA-RNA interaction that drives DPR production, suggesting a therapeutic target.

bioRxiv · Oct 28, 2026 · PreprintMolecular Biology

Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation

Clare M. Wieland, Shannon E. Wright, Sydney Willey, Ishita Purwar, Samantha Grudzien, Amy Krans, Erinn L. Laimon-Thomson, Melissa J. Asher, Adrian M. Isaacs, Amanda L. Garner, Peter K. Todd

The paper shows that neurons prefer cap-independent RAN translation from specific repeats, linked to altered start codon stringency and eIF1 redistribution.

Nucleic Acids Research · Sep 7, 2026Peer-reviewedNeuroscience

Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation

Shannon L. Miller, Katelyn M. Green, Bradley Crone, Jessica A. Switzenberg, Elizabeth M.H. Tank, Amy Krans, Karen R. Jansen‐West, Clare M. Wieland, Eric W. Ji, Leonard Petrucelli, Sami J. Barmada, Alan P. Boyle, Peter K. Todd

The paper identifies cryptic intronic C9orf72 transcripts as endogenous templates for RAN translation, leading to DPR production in ALS/FTD.

Proceedings of the National Academy of Sciences · Aug 4, 2025Peer-reviewedNeuroscience

TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms

Megan M. Dykstra, Kaitlin Weskamp, Nicolás Gómez, Jacob Waksmacki, Elizabeth M.H. Tank, M. Rebecca Glineburg, Allison G. Snyder, Emile S. Pinarbasi, Michael E. Bekier, Xingli Li, Jen Bai, Shameena Shahzad, Juno Nedumaran, Clare M. Wieland, Corey Stewart, , Sami J. Barmada

This study identifies TDP43 autoregulation as a source of shortened isoforms, showing they are regulated by NMD and post-translational degradation, and their dysregulation leads to neurodegeneration.

bioRxiv · Jul 2, 2024 · PreprintNeuroscience