Megan M. Dykstra

This study shows that cocaine exposure increases calreticulin in the ventral hippocampus via ΔFosB, reducing excitability in the vHPC-NAc circuit and promoting cocaine seeking and reward.

This study identifies TDP43 autoregulation as a source of shortened isoforms, showing they are regulated by NMD and post-translational degradation, and their dysregulation leads to neurodegeneration.

The paper develops NMDq, a next-generation sequencing method to quantify NMD status, and applies it to ALS and FTD, finding no significant PTC differences but showing UPF1 regulates RNA homeostasis through alternative polyadenylation.