C-terminal lysine residues localise NLRP10 at lipid compartments and govern NLRP10 oligomer formation
Timo-Daniel Voß, Christoph Winterberg, Adrian Beck, Clarissa Gottschild, Leonie Mueller, Selina M. Enayat, Matthias Geyer, Thomas A. Kufer
This study identifies the C-terminal lysine residues of NLRP10 as critical for its localization to lipid compartments and oligomer formation, highlighting unique activation mechanisms compared to other NLRPs.
bioRxiv · Nov 27, 2025 · PreprintImmunology