Matthias Geyer

NLRP3 acts as a direct sensor of intracellular potassium ions

This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.

Evolutionary algorithms accelerate de novo design of potent Nectin-4-specific cancer biologics

This paper combines evolutionary algorithms with AI to design potent Nectin-4-specific cancer biologics, achieving high-affinity minibinders and functional reagents.

Quantitative modeling of P-TEFb mediated CTD phosphorylation identifies local cooperativity

The paper uses mathematical modeling to show P-TEFb phosphorylates CTD repeats with local cooperativity but no directional bias.

C-terminal lysine residues localise NLRP10 at lipid compartments and govern NLRP10 oligomer formation

This study identifies the C-terminal lysine residues of NLRP10 as critical for its localization to lipid compartments and oligomer formation, highlighting unique activation mechanisms compared to other NLRPs.

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

Inhibition of NLRP3 by a CNS-penetrating indazole scaffold

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination

This study shows NLRP3 promotes homologous recombination by interacting with REV7, enhancing DNA repair and affecting PARP inhibitor sensitivity.

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins

This paper develops AI-designed protein binders for cancer cell surface proteins, showing their effectiveness in detection and targeting through experimental validation and benchmarking of structure prediction models.

The MYCN/Aurora-A complex is a cyclin activating kinase for CDK12

This study identifies Aurora-A as a CDK12-activating kinase in neuroblastoma, showing its role in transcription termination and tumor growth suppression.

The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease

This study identifies the SAVED domain of CalpL as a ring nuclease that cleaves cA4, revealing its role in regulating the CRISPR defense system.

Non-decameric NLRP3 forms an MTOC-independent inflammasome

The paper identifies two distinct NLRP3 activation pathways, one dependent on decameric cage formation and another independent of the MTOC and TGN.

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.