Mucosal delivery of influenza antigens using a replication deficient adenovirus supports broadly reactive antibody responses and heterologous viral immunity in the respiratory tract of animals
Michael D. Schultz, Davide Botta, Aarón Silva-Sánchez, Isabella R. Cheatwood, Davies Kalange, Sarah M. Terapane, Aaron C. K. Lucander, Fen Zhou, Jobaida Akther, Guang Yang, Mary E. Cockerham, William O. Stover, John A. Hall, Dinesh Kumar Yadav, Douglas Fox, , Frances E. Lund
This study shows that intranasal delivery of influenza antigens via a replication-deficient adenovirus induces broader antibody responses and better viral immunity in the respiratory tract compared to systemic delivery.
bioRxiv · Oct 13, 2025 · PreprintImmunology