Inorganic pyrophosphate disrupts amorphous hydrated bone mineral interfaces in hypophosphatasia
Scott Dillon, Amelia Armiger, Adrian Murgoci, Linda Skingle, Fabiana Gouveia Alves Tabegna, Sarah McDonald, Steven R. Mumm, Michael P. Whyte, Mark J. Garton, Kenneth E. S. Poole, Melinda Jane Duer
This study shows that inorganic pyrophosphate disrupts amorphous bone mineral interfaces in hypophosphatasia, leading to brittle fractures and altered mineral structure.
bioRxiv · Nov 24, 2025 · PreprintBiophysics