Melinda Jane Duer

TGF-β- and IL-1-dependent fibroblast states differentially shape pancreatic cancer microenvironments and metastasis

This study shows that TGF-β-dependent myCAFs promote pancreatic cancer metastasis, while IL-1-dependent iCAFs do not, through distinct signaling mechanisms.

Preserving Integrity: Innovative In Vitro Methods for Extracellular Matrix Decellularization and Collagen Purification

The paper develops and validates new methods for ECM decellularization and collagen purification that preserve structural and biochemical integrity, applicable to various cell types for tissue engineering and drug discovery.

Inorganic pyrophosphate disrupts amorphous hydrated bone mineral interfaces in hypophosphatasia

This study shows that inorganic pyrophosphate disrupts amorphous bone mineral interfaces in hypophosphatasia, leading to brittle fractures and altered mineral structure.

Lysyl oxidase-mediated intermolecular crosslinks fine-tune collagen I molecular dynamics and regulate cell-matrix interactions through focal adhesions

This study shows that LOX-mediated collagen crosslinking affects collagen dynamics and cell-matrix interactions through focal adhesions.

Molecular flexibility of high molecular weight hyaluronic acid measured by NMR has a profound effect on invasion of cancer cells

This study shows high molecular weight hyaluronic acid, when diluted, induces cancer cell migration via CD44 binding due to increased molecular flexibility, affecting cell morphology and proteome.

A Novel FNDC1-NAMPT-NAD axis is Implicated in Small and Large-vessel Arterial Disease and Drives Vascular Calcification

This study identifies FNDC1 as a key regulator of vascular calcification through the FNDC1-NAMPT-NAD axis, showing its role in both microvascular and macrovascular diseases and its potential as a therapeutic target.

Poly(ADP-ribose) binding sites on collagen I fibrils for nucleating intrafibrillar bone mineral