Scott Dillon

This study investigates the synergistic roles of TNAP and PHOSPHO1 in postnatal bone mineralisation using a novel murine knockout model, revealing their critical function in biomineralisation and skeletal development.

This study shows that inorganic pyrophosphate disrupts amorphous bone mineral interfaces in hypophosphatasia, leading to brittle fractures and altered mineral structure.

This study characterizes the proteome of matrix vesicles from primary osteoblasts, revealing a heterogeneous population with features of both exosomal and ectosomal biogenesis.

This study shows that LOX-mediated collagen crosslinking affects collagen dynamics and cell-matrix interactions through focal adhesions.

This study identifies mitochondrial dysfunction and impaired mitophagy in CKD-MBD as contributors to renal osteodystrophy, showing reversible effects with rapamycin treatment.

This study shows that increased PHOSPHO1 expression in renal osteodystrophy contributes to increased cortical bone mineral density but decreased trabecular bone density.