Reconstitution of adrenocortical functional zonation from human pluripotent stem cells
Michinori Mayama, Eoin Christopher Whelan, Takeshi A. Sato, David G. Stouffer, Adrian N. Leu, Jerome F. Strauss, Richard Joseph Auchus, Kotaro Sasaki
This paper develops a human pluripotent stem cell-derived adrenal organoid system that recapitulates adrenal zonation and demonstrates its utility for studying adrenal development and disease.
bioRxiv · May 24, 2025 · PreprintDevelopmental Biology