Richard Joseph Auchus

This study shows 19-Atriol inhibits steroidogenesis by directly targeting 3β-HSD and other enzymes, not via TSPO, resolving a long-standing mechanistic confusion.

This paper develops a human pluripotent stem cell-derived adrenal organoid system that recapitulates adrenal zonation and demonstrates its utility for studying adrenal development and disease.

This study generates human fetal zone adrenal cortex-like cells from induced pluripotent stem cells, revealing key signaling pathways and transcription factors involved in adrenocortical specification and steroidogenesis.

The paper demonstrates an alternative androgen biosynthesis pathway in human fetal females with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency, leading to virilization despite low circulating androgens.