Molecular flexibility of high molecular weight hyaluronic acid measured by NMR has a profound effect on invasion of cancer cells
Uliana Bashtanova, Agne Kuraite, Rakesh Rajan, Melinda Jane Duer
This study shows high molecular weight hyaluronic acid, when diluted, induces cancer cell migration via CD44 binding due to increased molecular flexibility, affecting cell morphology and proteome.
Royal Society Open Science · Aug 1, 2025Peer-reviewedCancer Biology