Neutrophil remodeling is associated with human meibomian gland dysfunction and enables IFN-γ- and PAD4-dependent gland obstruction in mice
Cole J. Beatty, Symon Ma, Oleg Kolupaev, John Bradley Cart, Hazem M. Mousa, Rose Mathew, Daniel J. Floyd, John M. Fallon, Kevin R. Kipp, Justyna Resztak, Zhuoya Wan, Areej Ammar, Sejiro Littleton, Yu Chen, Eden M. Jacob, , Daniel R. Saban
This study identifies a remodeled neutrophil state associated with meibomian gland dysfunction, showing IFN-γ and PAD4-dependent obstruction in mice.
bioRxiv · Aug 24, 2026 · PreprintImmunology