Author

Sejiro Littleton

Duke UniversityORCID 0000-0002-4845-4170Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:spatial transcriptomics· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Daniel R. SabaniD· 3 shared Joan KalnitskyiD· 2 shared Victor L. PereziD· 2 shared Yu CheniD· 2 shared Agnes Acevedo Canabal· 1 shared Allison M. Nguyen-ThaiiD· 1 shared Anna MatyniaiD· 1 shared Areej Ammar· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

Daniel R. SabanORCID

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3 papers

Recent·Most cited

stMCP: Spatial Transcriptomics with a Model Context Protocol Server

Jordan J. Smith, Xi Wang, M.T. McPheeters, Made Airanthi K. Widjaja‐Adhi, Sejiro Littleton, Daniel R. Saban, Marcin Golczak, Michael W. Jenkins

The paper introduces stMCP, a framework for spatial transcriptomics analysis using natural language-driven protocols, enabling local execution and reducing data privacy and cost concerns.

BMC Bioinformatics · Oct 7, 2026Peer-reviewedBioinformatics

Neutrophil remodeling is associated with human meibomian gland dysfunction and enables IFN-γ- and PAD4-dependent gland obstruction in mice

Cole J. Beatty, Symon Ma, Oleg Kolupaev, John Bradley Cart, Hazem M. Mousa, Rose Mathew, Daniel J. Floyd, John M. Fallon, Kevin R. Kipp, Justyna Resztak, Zhuoya Wan, Areej Ammar, Sejiro Littleton, Yu Chen, Eden M. Jacob, , Daniel R. Saban

This study identifies a remodeled neutrophil state associated with meibomian gland dysfunction, showing IFN-γ and PAD4-dependent obstruction in mice.

bioRxiv · Aug 24, 2026 · PreprintImmunology

The Cornea Harbors a Tricellular Neuro-Immune Niche that Underpins Touch Sensation

Sejiro Littleton, EM Jacob, Yu Chen, Emily G. O’Koren, Nancy Suyapa Reyes, R Matthew, Joan Kalnitsky, Seitaro Komai, Allison M. Nguyen-Thai, Sachin Parikh, W Perez, S Mitra, J Neff, Florent Ginhoux, Victor L. Perez, , Daniel R. Saban

The paper identifies a tricellular niche in the cornea involving macrophages, nerves, and Schwann cells that supports Piezo2-mediated touch sensation.

bioRxiv · Jul 28, 2025 · PreprintImmunology