Daniel R. Saban

The paper introduces stMCP, a framework for spatial transcriptomics analysis using natural language-driven protocols, enabling local execution and reducing data privacy and cost concerns.

This study identifies a remodeled neutrophil state associated with meibomian gland dysfunction, showing IFN-γ and PAD4-dependent obstruction in mice.

The paper identifies a tricellular niche in the cornea involving macrophages, nerves, and Schwann cells that supports Piezo2-mediated touch sensation.

The paper identifies resident tissue macrophages as critical for maintaining intraocular pressure homeostasis by regulating extracellular matrix turnover in the trabecular meshwork.

The paper uses spatial transcriptomics to study chemokine expression in granulomas formed by Chromobacterium violaceum infection, showing that CCR2 is critical for macrophage organization and bacterial containment.

The paper shows that microglia in specific brain regions exhibit premature aging-related inflammation in middle age, which may affect nearby neurons.

The paper shows that retinal astrocytes undergo large-scale death during development, mediated by microglia rather than apoptosis, leading to anatomical and functional changes in the retinal network.