Author

Agnes Karasik

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 3

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Nicholas R. GuydoshiD· 3 shared Andrew V. DePassiD· 2 shared Grant D. Jones· 2 shared Hernán LorenziiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 5 mutual co-author links

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3 shared papersMolecular Biology

Nicholas R. GuydoshORCID

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3 papers

Recent·Most cited

Stalled translation on transcripts cleaved by RNase L activates signaling important for innate immunity

Agnes Karasik, Grant D. Jones, Nicholas R. Guydosh

The paper shows that RNase L cleavage of mRNAs leads to ribosome stalling, which activates innate immunity via the ribotoxic stress response.

RNA · Feb 26, 2026Peer-reviewedMolecular Biology

Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response

Agnes Karasik, Hernán Lorenzi, Andrew V. DePass, Nicholas R. Guydosh

The paper shows that RNase L-mediated RNA fragmentation during the innate immune response triggers antiviral outcomes through ZAK signaling and inhibits translation of stress-responsive genes.

Cell Reports · May 30, 2024Peer-reviewedMolecular Biology

Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences

Agnes Karasik, Grant D. Jones, Andrew V. DePass, Nicholas R. Guydosh

The paper investigates how RNase L activation affects translation of non-coding mRNA sequences by analyzing ribosome distribution in human cells.

Nucleic Acids Research · Feb 4, 2021Peer-reviewedMolecular Biology