Nicholas R. Guydosh

The paper quantifies disome levels across the transcriptome in yeast and human cells under basal and stress conditions, showing stress-induced increases and context-dependent redistribution.

This study shows RSV competes with host mRNAs for ribosomes without using host shutoff strategies, and avoids activating antiviral pathways that reduce cap-dependent translation.

The paper shows that RNase L cleavage of mRNAs leads to ribosome stalling, which activates innate immunity via the ribotoxic stress response.

This study shows RSV optimizes translational efficiency by increasing polysome formation and enhancing ribosome recruitment to AU-rich host and viral transcripts through the M2-1 protein.

The paper shows that RNase L-mediated RNA fragmentation during the innate immune response triggers antiviral outcomes through ZAK signaling and inhibits translation of stress-responsive genes.

The paper shows Rad6 mediates ribosome pausing during oxidative stress, affecting translation and stress response pathways.

ribofootPrinter provides a Python toolkit for analyzing ribosome profiling data, offering simplicity and adaptability for specialized needs.

The paper investigates how RNase L activation affects translation of non-coding mRNA sequences by analyzing ribosome distribution in human cells.