Protamine lacunae preserve the paternal chromatin landscape in sperm
Thomas W. Tullius, Rachel A. Heuer, Stephanie C. Bohaczuk, Benjamin J. Mallory, Danilo Dubocanin, Jane Ranchalis, Ahmet Ayaz, Christopher E. Mason, Emre U Seli, Adam M. Phillippy, Andrew B. Stergachis, Bluma J. Lesch
The paper uses Fiber-seq to study paternal chromatin repackaging in sperm, finding that protamine lacunae and nucleosome retention play distinct roles in epigenetic inheritance.
bioRxiv · Oct 3, 2025 · PreprintGenomics