Author

Rachel A. Heuer

Yale UniversityORCID 0000-0002-4788-286XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Bluma J. LeschiD· 3 shared Benjamin William WaltersiD· 2 shared Shubhangini KatarukaiD· 2 shared Adam M. PhillippyiD· 1 shared Ahmet Ayaz· 1 shared Andrew B. StergachisiD· 1 shared Aushaq Bashir MallaiD· 1 shared Benjamin J. MalloryiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenetics

Bluma J. LeschORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 1, 2026

Paternal regulation of H3K4 methylation supports tumor suppressor networks in mammals intergenerationally

Benjamin William Walters, Rachel A. Heuer, Haoming Yu…·Bluma J. Lesch

The paper shows that paternal KDM6A loss disrupts H3K4 methylation at tumor suppressor gene promoters, increasing cancer risk in offspring.

DOI 10.64898/2026.08.28.747954

mouseDNA methylation

𝕏 PostBluesky

GenomicsbioRxivPreprintOct 3, 2025

Protamine lacunae preserve the paternal chromatin landscape in sperm

Thomas W. Tullius, Rachel A. Heuer, Stephanie C. Bohaczuk…·Bluma J. Lesch

The paper uses Fiber-seq to study paternal chromatin repackaging in sperm, finding that protamine lacunae and nucleosome retention play distinct roles in epigenetic inheritance.

4 citations

𝕏 PostBluesky

GeneticsProceedings of the National Academy of SciencesPeer-reviewedJul 31, 2025

ISWI chromatin remodeler SMARCA5 is essential for meiotic gene expression and male fertility in mammals

Shubhangini Kataruka, Aushaq Bashir Malla, Shannon R Rainsford…·Bluma J. Lesch

This study shows that SMARCA5 is essential for meiotic gene expression and male fertility by regulating chromatin accessibility during spermatogenesis.

10 citationstop 2%

mousebulk RNA-seq

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