Thomas W. Tullius

FiberBrowser converts diverse single-molecule footprinting datasets into a unified representation for analyzing chromatin structure and function across assays.

The paper investigates how neocentromeres reshape chromatin and identifies conserved features of native centromeres using haplotype-resolved assemblies and multi-omics data.

The paper identifies cis-regulatory modules in Drosophila that act as an intrinsic chromatin timer, setting temporal thresholds for gene expression during development.

The paper uses Fiber-seq to study paternal chromatin repackaging in sperm, finding that protamine lacunae and nucleosome retention play distinct roles in epigenetic inheritance.

This study shows plasmids can form chromatin structures in mammalian cells and uses plasmid Fiber-seq to map these structures and their functional consequences.

This study uses Fiber-seq to analyze TE regulatory potential in maize, revealing epigenetic patterns and gene interaction mechanisms.

The paper uses long-read single-molecule accessibility mapping to reveal that human mtDNA undergoes all-or-none global compaction, with most nucleoids in an inaccessible state.

The paper uses Fiber-seq to study RNA polymerase interactions with chromatin fibers, showing Pol II pausing affects nucleosomes and coordination between nearby transcriptional elements.