Cannabidiol attenuates chemotherapy-induced peripheral neuropathic pain through a mechanism that requires the enzyme N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD)
Carlos Henrique Alves Jesus, Ai-Ling Li, Serge H. Luquet, Ken Mackie, Andrea G. Hohmann
This study shows CBD reduces chemotherapy-induced neuropathic pain through NAPE-PLD and PPAR receptor pathways, but not CB1/CB2.
bioRxiv · Jun 12, 2026 · PreprintNeuroscience