Ken Mackie

This study examines how morphine alters lipid levels in different brain and body regions after acute or chronic administration, identifying potential endogenous lipid signaling systems involved in opioid reward and withdrawal.

This paper develops a human myelin microphysiological system to test treatment responses in multiple sclerosis patients, showing differential demyelination and immune responses between patient groups.

This paper develops an acoustofluidic patch for transdermal biosensing and drug delivery, demonstrating its ability to detect and reverse acute allergic reactions in mice.

This paper introduces Brainobot, a biohybrid robotic system using brain organoid reservoir computing to enable real-world decision-making tasks like object grasping and laser chasing with high efficiency and low energy consumption.

This study examines CBD interactions with fentanyl-bound MOR1 conformations using molecular dynamics simulations, finding state-dependent effects but limited inferential power due to small trajectory numbers.

This study shows CBD reduces chemotherapy-induced neuropathic pain through NAPE-PLD and PPAR receptor pathways, but not CB1/CB2.

The paper identifies compartment-specific changes in endolipid signaling during psoriasiform inflammation using lipidomic and transcriptomic analyses in mouse models.

This study shows that perinatal CBD exposure alters astrocyte morphology and tripartite synapse organization in a sex-dependent manner in the medial prefrontal cortex.

This study investigates the role of NAPE-PLD in opioid responsiveness and finds sex-dependent differences in oxycodone and sucrose consumption in knockout mice.

The paper shows acetaminophen inhibits DAGLα, reducing 2-arachidonoyl glycerol production and suggesting a novel antinociceptive mechanism involving DAGLα/CB1 circuits.

This paper introduces VID scaffolds to enhance diffusion in neural organoids, improving their function and drug response compared to conventional organoids.

This study shows that CB1 agonists like CP55,940 and THC cause respiratory depression in awake mice, contradicting previous beliefs about their minimal respiratory impact.

This study investigates how CB1 and CB2 receptors modulate cognitive effects of maternal immune activation and prenatal cannabis exposure in mice, finding differential roles in behavioral impairments.

This study shows that genetic deletion of NAPE-PLD in mice leads to anxiety-like behaviors and context-dependent dysregulation of the HPA axis, with sex-specific effects on corticosterone levels.

This study shows that deleting DAGLα in cerebellar Purkinje cells in mice leads to reduced social preference and increased anxiety.

This study identifies primary sensory neurons as the cell type mediating anti-allodynic effects of CB2 agonists and reveals a sexually dimorphic sparing of morphine tolerance in male mice.

This paper investigates the role of NAPE-PLD in the ventral tegmental area, showing its impact on reward behaviors, feeding, and energy homeostasis through transcriptomic analysis and genetic manipulations.

This study shows that CB2 receptors in peripheral sensory neurons are essential for the antinociceptive effects of CB2 agonists and their ability to reverse morphine tolerance in a neuropathic pain model.

This study shows that adolescent cannabinoid exposure reduces prefrontal reelin expression and impairs synaptic plasticity, mimicking reelin haploinsufficiency.

The paper uses deep learning to analyze cerebellar morphology across species, finding sex and cannabinoid signaling influence folding patterns.

This study examines how early-life stress affects cerebellar endocannabinoid levels and behavior, revealing sex-specific differences and potential contributions to brain sexual differentiation.

The paper identifies ABHD4 as a mediator of developmental anoikis that protects the prenatal brain from pathological insults by eliminating abnormally detached progenitor cells.

This study investigates sex-specific behavioral and neuronal deficits in adult rats exposed to prenatal cannabinoids, finding differences in social interaction, synaptic plasticity, and receptor expression between males and females.

This study shows that maternal cannabinoid exposure during lactation delays the GABA switch in prefrontal cortex neurons of rat offspring via a CB1R-dependent mechanism.