Nuclear remodeling and optimal migration emerge early, and constriction-passage progressively improves during hematopoietic stem cells to neutrophils differentiation
Allen Yesin, Kennedy Outlaw, Regina Sanchez Flores, Aichatou Doucoure, Ruth Hüttenhain, Hawa Racine Thiam
This study generates human neutrophils from HSCs and shows that migration speed, deformation through constrictions, and recovery from deformation emerge at different stages of differentiation.
bioRxiv · Sep 7, 2026 · PreprintCell Biology