Ruth Hüttenhain

This study shows the ER membrane protein complex (EMC) acts as a chaperone to facilitate the assembly of voltage-gated calcium channels during their biogenesis.

The paper uses human iPSC-derived neurons to study WNV effects, identifying strain-specific neuroattenuation and pathogenic signatures not seen in conventional cell lines.

This study generates human neutrophils from HSCs and shows that migration speed, deformation through constrictions, and recovery from deformation emerge at different stages of differentiation.

This paper optimizes and benchmarks synchro-PASEF for phosphoproteomics, showing improved identification and quantification with retention time summation, and comparable performance to dia-PASEF in modeling phosphosignaling.

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

V-SWITCH is a fluorescent reporter that detects viral infections by switching from OFF to ON fluorescence, enabling live-cell tracking and screening for antiviral strategies.

This paper introduces a scalable proximity proteomics pipeline that improves reproducibility and throughput in biotinylation-based spatial proteomics.

The paper constructs a PPI network of 100 high-confidence ASD genes, identifies novel interactions, and uses AlphaFold-Multimer to prioritize variants for functional validation in organoids.

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

The paper identifies novel regulators of mu opioid receptor signaling and trafficking using proximity labeling and proteomics.

The paper maps Tau interactomes in neurons using APEX and AP-MS to reveal activity-dependent interactions and FTD mutation effects on mitochondrial associations in neurodegenerative diseases.

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.