HLA-A*11:01-Restricted T Cell Receptors Targeting Mutant NPM1 for Adoptive Cell Therapy in Acute Myeloid Leukemia
Aidan Pursley, Uns Kirmani, Amanda Lin Chen, Zhiya Yu, Ken‐ichi Hanada, Catherine M. Ade, Christopher Daniel Chien, Nuri Cha, Willy A. Flegel, Peter D. Aplan, Martin P Carroll, Naomi N. Taylor, James Chih-Hsin Yang, Steven Zivko Pavletic, Sung‐Yun Pai, Vid Leko
This study identifies two TCRs targeting mutant NPM1 in AML for adoptive therapy, showing specific anti-leukemic activity without cross-reactivity.
bioRxiv · Oct 1, 2026 · PreprintImmunology