Martin P Carroll

Limits of marker information transfer]{Limits of marker information transfer in cross-panel cytometry imputation

This study evaluates the limits of marker information transfer in cross-panel cytometry imputation, finding that imputation preserves broad lineage classification but not fine-phenotype details, and that patient matching improves cross-platform distribution recovery.

Apoptotic Cells Promote Tim4+ Macrophage Differentiation Through Direct and Indirect Signaling Pathways

This study shows that apoptotic cells promote Tim4+ macrophage differentiation through both direct and indirect signaling pathways involving efferocytosis and IL-4R-STAT6 signaling.

HLA-A*11:01-Restricted T Cell Receptors Targeting Mutant NPM1 for Adoptive Cell Therapy in Acute Myeloid Leukemia

This study identifies two TCRs targeting mutant NPM1 in AML for adoptive therapy, showing specific anti-leukemic activity without cross-reactivity.

Somatic DDX41 mutations confer neomorphic splicing activity in the pathogenesis of myelodysplastic neoplasms

This study identifies somatic DDX41 mutations as gain-of-function alleles that drive aberrant splicing, particularly of SEPTIN7, contributing to MDS/AML pathogenesis.

Human CEBPA-N AML exhibits enhanced engraftment and a C/EBPα-p30-driven leukemic stem cell program

This study identifies CEBPA-N-AML as having enhanced engraftment and defines a novel LSC signature in CEBPA-N-AML.

CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia

This study identifies CEBPD as a tumor suppressor gene in acute myeloid leukemia through functional experiments and genomic analyses.

Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate

This study shows pitavastatin overcomes venetoclax resistance in AML by depleting GGPP, inducing apoptosis through PUMA upregulation and MCL-1 reduction, and suppressing mitochondrial metabolism.

A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist

The paper develops patient-derived AML PDX models that replicate primary AML biology and include subgroups lacking existing models, showing reduced leukemia growth after long-term chemotherapy.

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

DNA methylation calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation

The paper evaluates DNA methylation calling tools for Oxford Nanopore sequencing using human data and provides an online database for comparing tool performance.

Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia

The paper shows that alternative splicing contributes to gene disruption in AML, increasing the number of patients with functional gene loss beyond what is detected by mutations alone.