Sigma-2 Receptor Modulators Alter Low-density Lipoprotein Receptor-mediated Lipid Uptake in Retinal Pigment Epithelial Cells
Britney N. Lizama, Aidan Reaver, Gary C. Look, Anthony O. Caggiano, Mary E. Hamby
This study shows that sigma-2 receptor modulators increase LDL uptake in RPE cells via TMEM97 and LDLR, supporting their potential therapeutic use in dry AMD.
Experimental Eye Research · Feb 25, 2026Peer-reviewedCell Biology