Mary E. Hamby

Sigma-2 Receptor Modulators Alter Low-density Lipoprotein Receptor-mediated Lipid Uptake in Retinal Pigment Epithelial Cells

This study shows that sigma-2 receptor modulators increase LDL uptake in RPE cells via TMEM97 and LDLR, supporting their potential therapeutic use in dry AMD.

Multi-omics comparative analyses of synucleinopathy models reveal distinct targets and relevance for drug development

The paper compares two rat synucleinopathy models using multi-omics data to identify disease mechanisms and drug targets relevant to Parkinson's disease.

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease

The paper identifies transmembrane protein 97 as a synaptic receptor for amyloid beta in human Alzheimer's disease using advanced microscopy and drug intervention studies.

Homeostatic versus pathological functions of Dual Leucine Zipper Kinase in the adult mouse brain

This study investigates the context-specific roles of DLK/p-c-Jun signaling in the cerebellum and hippocampus, showing distinct effects on synaptic maintenance and neuroinflammation.