Somatostatin Receptors Shape Insulin and Glucagon Output within the Pancreatic Islet through Direct and Paracrine Effects
Ryan G. Hart, Jordan J. Lee, Karen Zhai, Sharlene Lee, Rashita Chauhan, Aidean Hosseini, Austin D. Nguyen, Mark O. Huising
This study investigates how somatostatin receptors in pancreatic alpha and beta cells regulate hormone release, revealing differential effects of SSTR2 and SSTR3 on cAMP and Ca2+ signaling and paracrine interactions.
Diabetologia · Jun 20, 2026Peer-reviewedPhysiology