Mark O. Huising

Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets

This study compares the mechanisms of FFAR4 agonist-induced insulin secretion in mouse and human islets, finding indirect effects in mice and direct effects in humans.

Somatostatin Receptors Shape Insulin and Glucagon Output within the Pancreatic Islet through Direct and Paracrine Effects

This study investigates how somatostatin receptors in pancreatic alpha and beta cells regulate hormone release, revealing differential effects of SSTR2 and SSTR3 on cAMP and Ca2+ signaling and paracrine interactions.

Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of GCK-MODY

This paper investigates sex-dependent effects of dorzagliatin and incretin on insulin secretion in a novel GCK-MODY mouse model, finding additive benefits in males but not females.

G protein-Coupled Receptor Associated Sorting ProteinGASP1 mediated trafficking of the Glucagon Like Peptide-1Receptor contributes to the development of tolerance toincretin drugs

This study shows that GASP1-mediated GLP-1R trafficking contributes to tolerance to incretin drugs, suggesting a strategy to prevent tolerance by biasing drug engagement toward G protein signaling.

Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

The paper shows that ECM and cell-cell adhesion coordinate to regulate islet aggregation, architecture, and functional maturation during development.

Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers

epiRomics: a multi-omics R package to identify and visualize enhancers

epiRomics integrates multi-omics data to identify and visualize enhancer regions using ChIP and histone data, with visualization in a stand-alone browser.

Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

This study shows TEAD1 regulates adult β-cell proliferation and function, maintaining glucose homeostasis by balancing quiescence and mature identity in mice and humans.